The first patient has received a pioneering human embryonic stem cell operation in the U.K. that doctors hope will be effective against a common cause of blindness. The procedure was performed on a 60-year-old woman with a condition called age-related macular degeneration (AMD) at London’s Moorfields Eye Hospital last month. The procedure was deemed successful and thus far there have been no complications. The doctors expect to know by December whether or not the woman has regained her sight. The study will recruit a total of 10 patients for the ongoing trial over an 18-month period.

age related macular degeneration

Age-related macular degeneration is a common eye condition and the leading cause of vision loss among people 50 and older, according to the National Eye Institute. When macular degeneration strikes, it affects the area of the eye that is important for allowing us to see fine details. The disease may progress very slowly so that a person barely notices any changes at all. Or, it might progress rapidly, causing significant vision loss. There are two forms of the condition: “wet” and “dry.” The wet form is usually caused by abnormal blood vessels that leak fluid or blood into the region of the macula, in the center of the retina. Wet macular degeneration almost always begins as dry macular degeneration. Dry macular degeneration is far more common and affects 90 percent of people with the condition. It occurs when there is a breakdown or thinning of the layer of retinal pigment epithelial (RPE) cells in the macula, which support the light-sensitive photoreceptor cells that are critical to vision.

vision with AMD

The current trial, which is part of the London Project to Cure Blindness, will test the safety and efficacy of transplanting RPE cells derived from stem cells to treat people with sudden severe visual loss from wet age-related macular degeneration. In the procedure, these cells are used to replace those at the back of the eye that are diseased with the condition, through a specially engineered patch inserted behind the retina. The operation lasts one to two hours.

“There is real potential that people with wet age-related macular degeneration will benefit in the future from transplantation of these cells,” retinal surgeon Professor Lyndon Da Cruz from Moorfields Eye Hospital, who is performing the operations and co-leading the London Project, said.

The London Project was founded 10 years ago with the aim of curing vision loss in patients with wet AMD, and is the result of a partnership between Moorfields Eye Hospital, the UCL Institute of Ophthalmology, and the National Institute for Health Research (NIHR).


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